1,6-dimesyl-3,4-dimethyl-d-mannitol and a process for the...

Details 1,6-dimesyl-3,4-dimethyl-d-mannitol and a process for the... 1,6-dimesyl-3,4-dimethyl-d-mannitol and a process for the...

C - Chemistry, Metallurgy

07

C

260/464.7

C07C 309/66 (2006.01)

Patent

CA 1112660

ABSTRACT OF THE DISCLOSURE The invention relates to 1,6-dimesyl-3,4-dimethyl- D-mannitol of the formula (I), Image (I) wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D- mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), Image (III) wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.

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