1,6-naphthyridine derivatives as antidiabetics

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) C07D 221/00 (2006.01)

Patent

CA 2463039

The invention relates generally to naphthyridine derivatives of the formula (A), wherein one of U, X, Y and Z is nitrogen and the others are C-R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6- naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.

D'une manière générale, l'invention concerne des dérivés de naphthyridine représentés par la formule (A), dans laquelle l'un des radicaux suivants, U, X, Y et Z représente azote tandis que les autres représentent C-R, où R représente hydrogène ou un substituant. D'une manière plus spécifique, l'invention concerne des dérivés de 1,6-naphthyridine et des compositions pharmaceutiques contenant ces dérivés. L'invention concerne également des méthodes qui consistent à administrer un dérivé de naphthyridine pour le traitement du diabète et de troubles associés.

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