[1,7]naphthyridines as pde4 inhibitors

Details [1,7]naphthyridines as pde4 inhibitors [1,7]naphthyridines as pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2505405

Compounds of Formula (I) in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-.alpha. release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

L'invention concerne des composés de formule générale (I) sous forme libre ou sous forme de sel, dans laquelle R?1¿, R?2¿ et R?3¿ ont la signification indiquée dans la description, utiles pour le traitement d'états dont la médiation est assurée par la phosphodiestérase de type 4 ou par la diminution ou l'inhibition de libération de TNF-.alpha., en particulier les maladies respiratoires obstructives ou inflammatoires. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés ainsi que des procédés de préparation de ces derniers.

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