1-8 benzonaphtyridine derivatives, preparation and...

C - Chemistry – Metallurgy – 07 – D

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167/223, 260/266

C07D 471/04 (2006.01) A61K 31/495 (2006.01)

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CA 2028730

BREVET D'INVENTION NOUVEAUX DERIVES DE BENZONAPHTYRIDINE-1,8, LEUR PREPARATION ET LES COMPOSITIONS QUI LES CONTIENNENT LABORATOIRE ROGER BELLON ABREGE Nouveaux dérivés de benzo[b]naphtyridine-1,8 de formule générale (I) dans laquelle R1 est un atome d'hydrogène ou un radical hydroxy ou alcoyle, R2 est un atome d'hydrogène ou un radical alcoyle, fluoroalcoyle, cycloalcoyle (3 à 6 C), alcoyloxy ou alcoylamino, R3 est un radical phényle ou phénylalcoyle substitué par un ou plusieurs atomes d'halogène ou radicaux alcoyle, cycloalcoyle (3 à 6 C), alcoyloxy, cyano, amino, alcoylamino, dialcoylamino, alcoyloxy- alcoyle, hydroxyalcoyle, hydroxyalcoyloxy, méthylènedioxy, amino- alcoyle, alcoylaminoalcoyle ou dialcoylaminoalcoyle, ou R3 est un radical hétérocyclyle, et R4 est un atome d'hydrogène ou un atome de fluor, les radicaux alcoyle (1 à 4 C) étant droits ou ramifiés, leurs sels, leur préparation et les compositions qui les contiennent. Ces nouveaux produits sont utiles comme antimicrobiens, ou dans le traitement du SIDA. Image (I)

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