1,8-naphthalimide imidazo[4,5,1-de]acridones with anti-tumor...

Details 1,8-naphthalimide imidazo[4,5,1-de]acridones with anti-tumor... 1,8-naphthalimide imidazo[4,5,1-de]acridones with anti-tumor...

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/437 (2006.01) A61K 31/4745 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2402446

The invention provides imidazoacridone compounds of general formula (1) which have cytotoxic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirably high levels of cell proliferation. The compounds of the invention are also expected to have utility as research tools.

L'invention concerne des composés d'imidazoacridone correspondant à la formule générale (1) et possédant une activité cytotoxique et antitumorale. L'invention concerne également des méthodes de préparation desdits composés, ainsi que des méthodes d'utilisation correspondantes dans le traitement du cancer ou d'autres maladies des mammifères caractérisées par une prolifération cellulaire excessive. Les composés de l'invention peuvent s'utiliser également en tant qu'outils pour la recherche.

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