1,8-naphthyridin-2-one derivatives

Details 1,8-naphthyridin-2-one derivatives 1,8-naphthyridin-2-one derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/262

C07D 471/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2040517

Disclosed are naphthyridine derivatives repre- sented by formula (I) Image (I) wherein: X represents hydrogen; lower alkyl; aralkyl; substi- tuted or unsubstituted aryl; substituted or unsubstituted aromatic heterocyclic group; -NR1R2 wherein R1 and R2 independently represent hydrogen or lower alkyl; Image wherein W represents N or CH, Z represents a single bond, oxygen or NR3 (wherein R3 repre- sents hydrogen, lower alkyl or benzyl) and n1 and n2 repre- sent an integer of 1 to 3; or substituted or unsubstituted thiazolinyl; and Y is a single bond or alkylene and pharmaceutically acceptable salts thereof. The compounds show potent anti-inflammatory activity and are expected to be useful in treating rheumarthritis.

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