C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C12N 9/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2299617
The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D 1-.alpha.-Hydroxylase and polypeptides encoded thereby. It encompasses antibodies to the polynucleotides and hybridizing polynucleotides. The polynucleotides and polypeptides are used in methods of diagnosing and treating vitamin D-related disorders and of producing vitamin D metabolites. The invention also encompasses expression vectors and animal cells comprising the polynucleotides.
L'invention concerne des polynucléotides codant une partie ou la totalité du fragment P450 de la 1-.alpha.-hydroxylase de la vitamine D, ainsi que les polypeptides codés par ces polynucléotides. L'invention concerne également des anticorps de ces polynucléotides et des polynucléotides d'hybridation. Les polynucléotides et les polypeptides sont utilisés dans des méthodes diagnostiques et des procédés de traitement des dysfonctionnements liés à la vitamine D, et dans des procédés de production de métabolites de vitamine D. L'invention concerne enfin des vecteurs d'expression et des cellules animales renfermant lesdits polynucléotides.
Glorieux Francis H.
St-Arnaud Rene
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Shriners Hospitals For Children
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