1-acetic acid-indole derivatives with pgd2 antagonist activity

Details 1-acetic acid-indole derivatives with pgd2 antagonist activity 1-acetic acid-indole derivatives with pgd2 antagonist activity

C - Chemistry, Metallurgy

07

D

C07D 209/30 (2006.01) A61K 31/405 (2006.01) A61P 11/00 (2006.01) A61P 37/00 (2006.01) C07D 209/42 (2006.01)

Patent

CA 2601980

Compounds of general formula: (I) wherein R1 is halo or cyano; R2 is C1-C4 alkyl; and R3 is phenyl substituted with one or more substituents chosen from C1-C6 alkyl, halo or -SO2(C1-C6 alkyl); or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof; are useful in the treatment of diseases and conditions mediated by the action of PGD2 at the CRTH2 receptor.

L~invention concerne des composés répondant à la formule générale : (I) dans laquelle R1 représente un groupe halogéno ou cyano ; R2 représente un groupe alkyle en C1 à C4 ; et R3 représente un groupe phényle substitué par un ou plusieurs substituants choisis parmi un groupe alkyle en C1 à C6, un groupe halogéno ou -SO2(alkyle en C1 à C6) ; ou un sel, un hydrate, un produit de solvatation, un complexe ou un promédicament de ceux-ci acceptable sur le plan pharmaceutique. Ces composés sont utiles dans le traitement de maladies et d~affections ayant pour origine l'action de PGD2 sur le récepteur CRTH2.

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