1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivate,...

Details 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivate,... 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivate,...

C - Chemistry, Metallurgy

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D

167/211, 260/251

C07D 401/06 (2006.01) C07D 215/233 (2006.01) C07D 215/42 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 1339663

The present invention relates to novel 1-acyl-2, 3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compound, processes for producing said compounds, intermediate compounds to produce said compounds and compositions containing said compounds with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites. The present invention is based on the selection of 1-acyl-7-halo-2,3-dihydro-4(1H)-quinolinone-4-oximme-O-sulfonic acid compounds, namely heterocyclic-or fused heterocyclic- carbonyl derivatives at 1 position. The compounds of the present invention containing these substituents have potent hypotensive, antioedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.

581642

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