1-acyl-2-(8 chloro-10,11-dihydrodibenz (b,f) (1,4)...

Details 1-acyl-2-(8 chloro-10,11-dihydrodibenz (b,f) (1,4)... 1-acyl-2-(8 chloro-10,11-dihydrodibenz (b,f) (1,4)...

C - Chemistry, Metallurgy

07

D

260/238.9

C07D 267/02 (2006.01) C07D 267/20 (2006.01)

Patent

CA 1050019

ABSTRACT OF THE DISCLOSURE _ _ _ 1-Acyl-2-(8-chloro-10,11-dihydrodibenz[b,f]- [1,4]-oxazepine-10-carbonyl)hydrazines are described herein. They are useful pharmacological agents as evidenced by their anti-convulsant, topical anti-inflam- matory, and prostaglandin and 5-hydroxytryptamine antagonist activity. These compounds are prepared by the reaction of 8-chloro-10,11-dihydrodibenz[b,f][1,4]- oxazepine-10 carboxylic acid hydrazide with an appropriate acylating agent. Carboxyllc acid chlorides and carboxylic acid anhydrides are preferred acylating agents.

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