1-alkoxy-(2-alkoxy- or cycloalkoxy)-4-(cyclo thioalkyl- or...

Details 1-alkoxy-(2-alkoxy- or cycloalkoxy)-4-(cyclo thioalkyl- or... 1-alkoxy-(2-alkoxy- or cycloalkoxy)-4-(cyclo thioalkyl- or...

C - Chemistry, Metallurgy

07

D

C07D 335/02 (2006.01) A61K 31/38 (2006.01) C07D 333/02 (2006.01) C07D 333/16 (2006.01) C07D 333/32 (2006.01) C07D 333/48 (2006.01)

Patent

CA 2130938

2130938 9318024 PCTABS00025 This invention is directed to 1-alkoxy-2-(alkoxy- or cycloalkyloxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-)benzene compounds that inhibit cyclic AMP phosphodiesterase or tumor necrosis factor (TNF) and are useful in treating patients suffering from disease state capable of being modulated by inhibiting production of cyclic AMP phosphodiesterase or TNF by administering the compound to the patient. The invention is also directed to the preparation of these compounds, pharmaceutical compositions containing these compounds and methods for their pharmaceutical use.

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