1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenyl hydrazines...

Details 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenyl hydrazines... 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenyl hydrazines...

C - Chemistry, Metallurgy

07

D

167/207, 260/287

C07D 215/36 (2006.01) C07D 231/18 (2006.01) C07D 261/10 (2006.01) C07D 333/18 (2006.01) C07D 333/34 (2006.01)

Patent

CA 1304383

NOVEL 1-ALKYL-1-SULFONYL-2- ALKOXYCARBONYLSULFENYLHYDRAZINES HAVING HAVING ANTINEOPLASTIC ACTIVITY ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image wherein R1 is a lower alkyl of 1-6 carbon atoms, benzyl, phenyl or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino, or carbonyl substituents, or -RN(R')2 wherein R and R' are each independently alkyl of 1 to 4 carbon atoms; R2 is an aromatic substituent, and each A is an aromatic substitution independently selected from the group consisting of hydrogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, halogen, -NO2, -NH2, -COOH, and -NHCOCH3. The compounds have been found to be alkylating agents having antineoplastic activity for use in inhibiting the growth of tumors.

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