C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61P 25/18 (2006.01) A61P 25/26 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2648157
The present invention relates to 3-aniIine-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
La présente invention concerne des dérivés 3-aniline-5-aryle de triazole de Formule (I) et des analogues ou des sels de qualité pharmaceutique desdits dérivés, ainsi que des procédés de synthèse desdits dérivés, des compositions pharmaceutiques les incluant et leur emploi en thérapie. L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, un tel modulateur allostérique positif ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.
de Bruyn Marcel Frans Leopold
Dinklo Theodorus
Duffy James Edward Stewart
Lesage Anne Simone Josephine
Macdonald Gregor James
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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