1-alkyl-substituted 1,4-dihydropyridinelactones, a process...

Details 1-alkyl-substituted 1,4-dihydropyridinelactones, a process... 1-alkyl-substituted 1,4-dihydropyridinelactones, a process...

C - Chemistry, Metallurgy

07

D

167/125, 167/229

C07D 491/048 (2006.01) A61K 31/695 (2006.01) C07D 211/90 (2006.01) C07D 491/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1249270

- 1 - 1-Alkyl-substituted 1,4-dihydropyridinelactones, a process for their preparation, and their use in medicaments Abstract Novel blood sugar-lowering dihydropyridinelactones of the formula Image in which R represents halogen, C1-C10-alkyl, C1-C10- alkoxy, C1-C10-alkylthio, C1-C10-alkyl- sulphinyl, C1-C10-alkylsulphonyl, cyano, C1-C6- mono- or polyfluoroalkyl, C1-C6-mono- or poly- fluoroalkoxy or nitro, R1 represents hydrogen, halogen or C1-C10- alkyl or C1-C10-alkoxy, R2 represents a C1-C20 straight chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which can optionally be inter- rupted by 1 or 2 oxygen atoms or -SOn- (n = 0, 1 or 2) and which can optionally be substituted by one or more fluorine, chlorine, bromine or iodine atoms, -NO2, -O-NO2, C3-C12-trialkylsilyl, -OH, -CN, amino, C1-C6-monoalkylamino, dialkyl- amino in which each alkyl is C1-C6, or benzyl- C1-C6-alkylamino, R3 represents hydrogen NH2, CHO, CN or a C1- C6 straight-chain or branched, saturated or un- saturated hydrocarbon radical which can be inter- rupted in the chain by oxygen, -NH- or -N-alkyl (1 to 6 C atoms), and R4 represents a C1-C10 straight-chain or branched alkyl or C2-C10-alkenyl radical which can optionally be interrupted by one or two oxygen atoms in the alkyl chain and which can optionally be substituted by one or more fluorine atoms, Cl, Br, I, CN, NH2, OH, aryl, hydroxycarbonyl, alkoxycarbonyl (1 to 10 C atoms in the alkoxy radical), -CHO, morpholino or C1-C4-dialkylamino, with the proviso that R is not CF3 if R2 represents C2H5.

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