1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d...

Details 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d... 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d...

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 3/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2648193

Disclosed are 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor- vitamin D compounds, pharmaceutical compositions, and methods of making and treatment thereof. The compounds are generally directed to biologically active 2-alkylidene-19-nor-vitamin D compounds and analogs thereof characterized by the presence of a 3'-hydroxypropylidene moiety at C-2 and the presence of an abbreviated alkyl side-chain free of any hydroxyl moiety.

L'invention concerne des composés de la 1.alpha.-hydroxy-2-(3'-hydroxypropylidène)-19-nor-vitamine D, des compositions pharmaceutiques ainsi que des procédés de production et de traitement associés. Ces composés sont généralement des composés de la 2-alkylidène-19-nor-vitamine D biologiquement actifs et des analogues associés, caractérisés par la présence d'une fraction 3'-hydroxypropylidène en C-2 et la présence d'une chaîne latérale alkyle abrégée sans aucune fraction hydroxyle.

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