1.alpha.-hydroxy-25-ene-vitamin d, analogs and uses thereof

Details 1.alpha.-hydroxy-25-ene-vitamin d, analogs and uses thereof 1.alpha.-hydroxy-25-ene-vitamin d, analogs and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2333270

The invention provides 1.alpha.-hydroxyvitamin D compounds in which the C-25 or equivalent position of the C-17 side chain has a double bond and their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment of bone depletive disorders.

L'invention concerne des composés de 1.alpha.-hydroxyvitamine D dans lesquels la position C-25 ou la position équivalente de la chaîne latérale C-17 présente une double liaison. Cette invention concerne en outre l'utilisation de ces composés pour prévenir et traiter l'hyperparathyroïdisme et les maladies hyperprolifératives, ainsi que pour moduler les réactions immunitaire et inflammatoire, ces composés pouvant également être utilisés pour traiter les déficits osseux.

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