C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/435 (2006.01)
Patent
CA 2122916
2122916 9311126 PCTABS00022 The invention concerns compounds of formula (I) wherein: R1, R2 and R3 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl or nitro; R6 is (a), (b) or (c) wherein R4 and R5 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, aryl, aryl (lower alkyl) wherein aryl contains 6 to 10 carbons atoms and lower alkyl contains 1 to 6 carbon atoms, alkanoyl of 2 to 5 carbon atoms or carboalkoxy, or R4 and R5 are joined to form alicyclic or heterocyclic rings selected from the group consisting of (d) wherein n = 1-10; (e) wherein X = O, S, SO, SO2; (f) wherein X = O, S; and (g) wherein R9 = H, lower alkyl containing 1 to 6 carbon atoms, aryl or aryl (lower alkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms, and R7 and R8 are independently alkylsulfoxy, arylsulfoxy, alkylsulfonyl, arylsulfonyl wherein aryl contains 6 to 10 carbon atoms and alkyl contains 1 to 6 carbon atoms or R8 may also represent one of the values for R5 above, and the pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
American Home Products Corporation
Ridout & Maybee Llp
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