1-amino-3-aryloxy-2-propanols

Details 1-amino-3-aryloxy-2-propanols 1-amino-3-aryloxy-2-propanols

C - Chemistry, Metallurgy

07

C

260/576.5, 260/5

C07C 59/72 (2006.01) C07C 41/30 (2006.01) C07C 43/215 (2006.01) C07C 45/68 (2006.01) C07C 217/38 (2006.01)

Patent

CA 1119190

Abstract of the Disclosure Compounds of formula I Image wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthio- alkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atoms to which R1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35. trifluoromethyl or cyano, R2 and R3 are either together straight chain alky- lene of 4 to 6 carbon atoms. or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is O then least one of R2 and R3 is other than hydrogen, and R4 and R5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders.

299681

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