1-amino-alkylcyclohexanes as 5-ht3 and neuronal nicotinic...

Details 1-amino-alkylcyclohexanes as 5-ht3 and neuronal nicotinic... 1-amino-alkylcyclohexanes as 5-ht3 and neuronal nicotinic...

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61K 31/40 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01) C07C 211/35 (2006.01) C07D 207/06 (2006.01)

Patent

CA 2410852

Certain 1-aminoalkylcyclohexanes are systematically-active 5HT3 and nicotinic receptor antagonists and are useful in the inhibition of progression of or alleviation of conditions resulting from disturbances of serotoninergic or nicotinergic transmission giving them a wide range of utility in the treatment of CNS-disorders. Pharmaceutical compositions thereof for such purpose and method of making same, as well as a method-of-treating conditions which are alleviated by the employment of a 5HT3 or neuronal nicotinic receptor antagonist.

Certains 1-aminoalkylcyclohexanes sont des antagonistes des récepteurs 5HT3 et nicotiniques actifs systématiquement et sont utiles dans l'inhibition de la progression ou dans le soulagement d'états résultant de perturbations de la transmission sérotoninergique ou nicotinergique leur conférant une large gamme d'utilités dans le traitement de troubles du système nerveux central. L'invention a trait à des compositions pharmaceutiques les contenant à cet effet et à leur procédé de production, de même qu'à une méthode de traitement d'états soulagés par l'utilisation d'un antagoniste des récepteurs 5HT3 ou nicotiniques neuronaux.

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