1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles

Details 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles

C - Chemistry, Metallurgy

07

D

260/315.3

C07D 231/12 (2006.01)

Patent

CA 1098527

ABSTRACT OF DISCLOSURE 1H-pyrazoles, said compounds having the formula: Image , said compounds being useful as anti-depressants and analgesics, are prepared by reduction with an alkali metal aluminum hydride of an .omega.-[1- (3,4-diphenyl-1H-pyrazolyl)]-lower alkanamide; reduction with hydrogen in the presence of ammonia, methylamine, dimeth- ylamine or diethylamine over a catalyst of a 1-(cyano-lower- alkyl)-3,4-diphenyl-1H-pyrazole; reaction of a 1-(tosyloxy- lower-alkyl)-3,4-diphenyl-1H-pyrazole with a lower-alkylamine; reaction of 3,4-diphenylpyrazole with a halo-lower-alkylation in the presence of an acid acceptor; or reductive alkylation with formaldehyde of a 1-(3-aminopropyl)-3,4-diphenyl-1H- pyrazole.

291869

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