1-amino triazolo[4,3-a]quinazolin-5-ones and or -5-thiones...

Details 1-amino triazolo[4,3-a]quinazolin-5-ones and or -5-thiones... 1-amino triazolo[4,3-a]quinazolin-5-ones and or -5-thiones...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2388658

The invention relates to triazolo[4,3-a]quinazoline-5-ones and/or 5-thiones of formula (I) or (II), whereby (I) and (II) are position isomers of group R on nitrogen 3 or 4. Optionally, the invention also relates to the racemic forms, isomers and pharmaceutically acceptable salts thereof. The invention further relates to a method for the production thereof and to compositions containing said derivatives. The compounds act as inhibitors of phosphodiesterase IV (PDE- 4).

La présente invention concerne des dérivés de Triazolo[4,3-a]quinazoline-5-ones et/ou -5-thiones de formule (I) ou (II): (I) et (II) étant des isomères de position du groupe R sur les azotes 3 ou 4, et éventuellement leurs formes racémiques et leurs isomères, ainsi que leur sels pharmaceutiquement acceptables, leur procédé de préparation et les compositions en contenant. Ces composés sont des inhibiteurs des phosphodiestérases 4 (PDE-4).

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