1-¬(aminoalkyl and aminoalkylamino)carbonyl and...

Details 1-¬(aminoalkyl and aminoalkylamino)carbonyl and... 1-¬(aminoalkyl and aminoalkylamino)carbonyl and...

C - Chemistry, Metallurgy

07

D

167/208, 260/277

C07D 207/09 (2006.01) C07D 207/08 (2006.01) C07D 211/28 (2006.01) C07D 211/34 (2006.01) C07D 211/42 (2006.01) C07D 223/04 (2006.01)

Patent

CA 1242439

ABSTRACT OF THE INVENTION 1-[(AMINOALKYL AND AMINOALKYLAMINO)CARBONYL AND THIOCARBONYL-.alpha.,.alpha.-DIARYLPYRROLIDINE, PIPERIDINE AND HOMOPIPERIDINEACETAMIDES AND ACETONITRILES Novel 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl-.alpha.,.alpha.-diaryl-pyrrolidine, piperidine and homo- piperidineacetamides and acetonitriles having the formula: Image wherein; n is zero, one or two; x is oxygen or sulfer; z is Image or -(CH2); p is 0 to 5 inclusive with the proviso that when z is Image , p is at least one; Y is aminocarbonyl or cyano; Ar1 and Ar2 are 2, 3 or 4-pyrido, phenyl or substituted phenyl; R is hydrogen or loweralkyl; R1, R2 and R3 are hydrogen, cycloalkyl, loweralkyl, phenyl, substituted phenyl, phenylloweralkyl, and R2 and R3 taken with the adjacent nitrogen may form a heterocyclic residue, and diastereoisomers when possible and pharmaceutical salts; and the method and pharmaceutical compositions for treating cardiac arrhythmias therewith are disclosed.

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