C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/279
C07D 209/04 (2006.01) A61K 31/40 (2006.01) C07D 209/10 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 1258070
ABSTRACT OF THE DISCLOSURE Disclosed are novel 2-R2-1-aminoalkyl-1H-indoles of the formula: Image (III) (wherein R2 is hydrogen, alkyl, chloro, optionally substituted phenyl or optionally substitued benzyl; R4 is hydrogen or one or two substituents; Alk is optionally alkyl-substituted alkylene; N=B is azido, optionally substituted amino or cyclic amino such as morpholinyl, thiomorpholinyl, piperidinyl, pyrrol.idinyl, azetidinyl, piperazinyl, hexahydrodiazepinyl, which may be substituted or the N=B N-oxide thereof) which themselves have analgesic activities and are also useful as intermediates for producing analgesic, anti-rheumatic or anti-inflammatory active substances of the formula: Image (I) (wherein R3 is optionally alkoxy-substituted cyclohexyl, optionally substituted phenyl, optionally substituted styryl, biphenyl, optionally substituted naphthyl thienyl, furyl, benzofuryl, benzothienyl, quinolyl or substituted pyrrolyl; Z is 0 or NOH; and the other symbols are defined above).
576124
Fetherstonhaugh & Co.
Sanofi-Synthelabo
Sterling Drug Inc.
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