1-aminocycloalkanealkanoic acids

Details 1-aminocycloalkanealkanoic acids 1-aminocycloalkanealkanoic acids

C - Chemistry, Metallurgy

07

D

260/518, 260/539

C07D 265/12 (2006.01) C07C 101/14 (1980.01)

Patent

CA 1087184

ABSTRACT There are described acids of the formula Image (I) wherein R and R1 are, independently, hydrogen or lower alkyl; X is hydrogen or methyl; Z is an amino group or an amino group protected with a removable blocking group and n is an integer from 1 to 5, and when n is 3 R2 is hydrogen, their salts and their derivatives useful as acylating agents for introducing the acyl group of the acid. The compounds are useful for the preparation of 6-[2-(1-aminocycloalkyl)acetamido-penicillanic acids end their salts which are anti-bacterial agents. The amino acids are prepared by hydrolysis of a B-lactam of formula Image where R, R1, R2 and n are as defined above. - 1 -

159027

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