1-(aminophenyl)-2-aminopropanone derivatives

Details 1-(aminophenyl)-2-aminopropanone derivatives 1-(aminophenyl)-2-aminopropanone derivatives

C - Chemistry, Metallurgy

07

D

260/267.1, 260/5

C07D 295/12 (2006.01) C07D 295/108 (2006.01)

Patent

CA 1240993

entitled: l-(Aminophenyl)-2-aminopropanone derivatives, in the name of: Société anonyme dite : LABORATOIRE L. LAFON inventor: Louis LAFON ABSTRACT OF THE DISCLOSURE The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: Image (I) in which X is NH2, Y is H or a halogen atom, Z is H or a halogen atom, R1 is C1-C4 alkyl or C3-C6 cycloalkyl and R2 is H or C1-C4 alkyl, or R1 and R2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl- piperazino, 4-(.beta.-hydroxyethyl)piperazino, 4-phenyl- piperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof. These new derivatives are useful as pharmaceuti- cals. They are obtained by deacetylation of the corres- ponding acetylated products.

488750

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