1-(aminophenyl)-2-pyrrolidones as integrin inhibitors

Details 1-(aminophenyl)-2-pyrrolidones as integrin inhibitors 1-(aminophenyl)-2-pyrrolidones as integrin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4025 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 207/277 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2393310

The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as .alpha.v.beta.3, .alpha.v.beta.5, .alpha.v.beta.6, .alpha.5.beta.1 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

L'invention concerne de nouveaux composés qui sont efficaces dans le cadre de la prophylaxie et du traitement de maladies, telles que des maladies à médiation par récepteurs d'intégrine, notamment des maladies ou des états induits par des récepteurs d'intégrine, tels que .alpha.¿v?.beta.¿3?, .alpha.¿v?.beta.¿5?, .alpha.¿v?.beta.¿6?, .alpha.¿5?.beta.¿1? et similaire. Cette invention concerne des composés nouveaux, des sels correspondants acceptables pharmaceutiquement, des compositions pharmaceutiques et des méthodes destinées à la prophylaxie et au traitement de tels maladies et troubles. Ladite invention a également trait à des procédés d'élaboration de tels composés ainsi qu'à des intermédiaires utilisés dans de tels procédés.

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