1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation...

Details 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation... 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation...

C - Chemistry, Metallurgy

07

D

260/472, 260/555

C07D 209/48 (2006.01) C07C 233/16 (2006.01)

Patent

CA 1137106

ABSTRACT OF THE DISCLOSURE Disclosed herein are novel D-(threo)-1-aryl-2-acylamido-3-fluoro- -1-propanols of the general formula I Image (I), and specified salts thereof, where R represents a specified alkyl, haloalkyl, halodeuteroalkyl, azidomethyl or methyl sulfonylmethyl group, X and X' independently represent a hydro- gen or halogen atom, a nitro, cyano or a substituted or unsubsti- tuted phenyl group or represent a group R1(A)n in which group n is zero or 1, A is oxygen, sulfur, carbonyl, sulfinyl or sulfonyl and R1 is a specified lower alkyl, amino or lower alkyl amino group and Z is hydrogen or a specified acyl group. The novel compounds exhibit antibacterial activity and their use for this purpose is disclosed. Also disclosed are methods for the preparation of the novel compounds as well as certain novel intermediates therefore.

344851

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