1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for...

Details 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for... 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for...

C - Chemistry, Metallurgy

07

D

260/241.4

C07D 223/16 (2006.01)

Patent

CA 1214460

Abstract of the disclosure 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines. a process for preparing the same and their use as medicaments The invention relates to 1-aryloxy-2,3,4,5-tetrahydro- 3-benzazepines of the formula Image wherein Y1 and Y2 are the same or different and are hydrogen or lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF3, NO2, CN and NH2; R is hydrogen, lower alkyl, cycloalkyllower alkyl, Image Ar lower alkyl of the formula -alkylene Image where Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF3, NO2 and NH2; and an alkylene amine of the formula -alkylene Image , where R1 and R2 are the same or different and are hydrogen and lower alkyl and the alkylene moiety is of 1 to 6 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof. The utility of the compounds of the present invention in the treatment of depression in mammals is demonstrated by their ability to inhibit tetrabenazine induced ptosis in mice.

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