C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/385, 260/515
C07D 295/14 (2006.01) C07D 295/092 (2006.01) C07D 295/112 (2006.01)
Patent
CA 1108633
HOE 76/F 115 NOVEL 1-ARYLOXY-2-HYDROXY-3-AMINOPROPANES AND PROCESS FOR PREPARING SAME Abstract of the disclosure: Compounds of formula I Image I wherein R1 and R1' are identical or different and represent hy- drogen, an alkyl radical or alkoxy radical having 1 - 4 carbon atoms, the allyl group, a halogen atom or the nitro group, R2 represents an acrylic acid radical or an acrylic acid nitrile radical of the formulae Image or Image wherein R5 represents hydrogen, an alkyl radical having 1 - 5 carbon atoms, an aryl radical or aryl-lower alkyl radical either unsubstituted or substituted by lower alkyl or alkoxy, R6 re- presents hydrogen or an alkyl radical having 1 - 8 carbon atoms, R7 represents hydrogen, a lower alkyl radical or an aryl-lower alkyl radical, R3 and R4 represent together with the nitrogen atom a hetero- cyclic ring with 5 - 7 members being optionally substituted by C1-C4 alkyl, in which ring one carbon atom may be replaced by one oxygen atom, sulfur atom or one further nitrogen atom, the latter may be substituted, or wherein R3 represents hydrogen and R4 represents a straight- chain or branched alkyl radical or oxalkyl radical having 1 - 8 carbon atoms, a straight-chain or branched unsaturated alipha- tic hydrocarbon radical having 2 - 6 carbon atoms, a cyclo ali- phatic hydrocarbon radical having 3 - 6 carbon atoms or a phenylalkylene radical or phenylalkylidene radical of formula Image wherein n is a figure from 1 - 3 and R8 and R9 are identical or different and represent hydrogen, an alkoxy radical having 1 - 3 carbon atoms or the benzoyl radical or R8 and R9 represent to- gether the bismethylene dioxy radical, as well as the physiologically compatible acid addition salts and a process for preparing these compounds. - 1a -
278974
Fritsch Werner
Lindner Ernst
Stache Ulrich
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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