1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use...

Details 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use... 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use...

C - Chemistry, Metallurgy

07

C

C07C 217/34 (2006.01) A61K 31/21 (2006.01) C07C 217/32 (2006.01) C07C 235/34 (2006.01)

Patent

CA 2128671

A B S T R A C T 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition. The above nitrate esters, having formula I: Image (I) the enantiomers and diastereoisomers and the therapeutically acceptable salts thereof, wherein R1 is a chain of general formula II - (CH2)m - Z - R2, where: m is 1 or 2; Z is an -O- ether, -CONH amide or -COO- ester function; and R2 is a C2-3 straight or branched chain alkyl having at least one nitroxy group as substituent; and Ar is a benzene ring when Z is the ether or ester function, and a naphthalene ring when Z is the amide function, are of use for the treatment of cardiovas- cular affections.

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