1-aryloxy-3-alkylamino-2-propanoles and processes for their...

C - Chemistry – Metallurgy – 07 – C

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C07C 33/00 (2006.01) A61K 31/045 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01)

Patent

CA 1147751

ABSTRACT OF THE DISCLOSURE The present invention relates to compounds of formula I Image (I) (wherein R1 represents a straight-chained or branched alkyl group with 1 to 20 carbon atoms and the acylamino group is in 4- or 6- position in the phenyl ring; and R3 represents a straight-chained or branched alkyl group with 3 to 10 carbon atoms, with the proviso that where R1 represents an ethyl group, R3 represents other than a tert.-butyl group) and acid addition salts thereof. The present invention also relates to processes for the preparation of compounds of formula I and their salts and to pharmaceutical compositions containing them. The compounds of formula I and their physiologically acceptable acid addition salts exhibit .beta.-adrenolytic and antihypotensive effects and may be used in the treatment of coronary diseases, cardiac arrhythmia and elevated blood pressure.

376193

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