C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/557
C07C 33/00 (2006.01) A61K 31/045 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01)
Patent
CA 1147751
ABSTRACT OF THE DISCLOSURE The present invention relates to compounds of formula I Image (I) (wherein R1 represents a straight-chained or branched alkyl group with 1 to 20 carbon atoms and the acylamino group is in 4- or 6- position in the phenyl ring; and R3 represents a straight-chained or branched alkyl group with 3 to 10 carbon atoms, with the proviso that where R1 represents an ethyl group, R3 represents other than a tert.-butyl group) and acid addition salts thereof. The present invention also relates to processes for the preparation of compounds of formula I and their salts and to pharmaceutical compositions containing them. The compounds of formula I and their physiologically acceptable acid addition salts exhibit .beta.-adrenolytic and antihypotensive effects and may be used in the treatment of coronary diseases, cardiac arrhythmia and elevated blood pressure.
376193
Koppe Herbert
Kummer Werner
Muacevic Gojko
Stahle Helmut
Traunecker Werner
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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