1-aryloxy-3-nitratoalkylamino-2-propanols and processes for...

Details 1-aryloxy-3-nitratoalkylamino-2-propanols and processes for... 1-aryloxy-3-nitratoalkylamino-2-propanols and processes for...

C - Chemistry, Metallurgy

07

D

260/317, 260/289

C07D 215/22 (2006.01) C07D 209/00 (2006.01) C07D 209/08 (2006.01)

Patent

CA 1129421

ABSTRACT OF THE DISCLOSURE Compounds of the formula Ar-O-CH2-CHOH-CH2-NH-R wherein Ar is phenyl; phenyl substituted by (a) halogen, (b) cyano, (c) C1-7 alkanoylamino, (d) benzoylamino, (e) alkanoyl of 1-4 carbon atoms, (f) C1-10 alkyl, (g) C1-10 alkoxy, alkoxyalkyl of up to 10 carbon atoms, alkoxyalkoxyalkyl of up to 10 carbon atoms, alkoxyalkoxy of up to 10 carbon atoms, C1-10 alkylthio, or alkylthio- alkyl of up to 10 carbon atoms, (h) alkenyl or alkynyl each of up to 10 carbon atoms, (i) alkenyloxy of up to 10 carbon atoms, alkenyloxyalkyl of up to 10 carbon atoms, alkynyloxy of up to 10 carbon atoms or alkynyloxyalkyl of up to 10 carbon atoms, (j) cycloalkyl of 3-8 carbon atoms or (k) cycloalkoxy of 3-8 carbon atoms; naphthyl; indanyl; indenyl; tetralyl; indolyl; indolyl substituted by alkyl of 1-4 carbon atoms; carbazolyl; or 1,2,3,4-tetrahydro-2- oxoquinoyl, and R is nitratoalkyl of 2-10 carbon atoms, and the physiologically acceptable acid addition salts thereof have valuable pharmacological properties, e.g., which make them useful for prophylaxis and treatment of heart problems, e.g., as .beta.-receptor blockers. They may be prepared by certain specified addition, solvolyzing or esterifying reactions.

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