1-aryloxy-4-amino-2-butanols

Details 1-aryloxy-4-amino-2-butanols 1-aryloxy-4-amino-2-butanols

C - Chemistry, Metallurgy

07

C

260/292, 260/294

C07C 45/71 (2006.01) C07C 43/196 (2006.01) C07C 43/23 (2006.01) C07D 211/14 (2006.01) C07D 211/70 (2006.01) C07D 213/64 (2006.01) C07D 215/06 (2006.01) C07D 217/04 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1077474

ABSTRACT OF THE DISCLOSURE Novel 1-aryloxy-4-amino-2-butanols of the formula ArO-CH2-CHOH-CH2CH2-NR1R2 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R1 is lower alkyl, phenyl, phenyl- alkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower cycloalkyl, R2 is hydrogen or lower alkyl, wherein R1 and R2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, alpha-adrenergic blocking, beta-adrenergic blocking and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro- 2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed - 1 -

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