1-aryloxy-4-amino-2-butanols

Details 1-aryloxy-4-amino-2-butanols 1-aryloxy-4-amino-2-butanols

C - Chemistry, Metallurgy

07

C

260/297, 260/557

C07C 43/20 (2006.01) C07D 213/61 (2006.01) C07C 103/38 (1980.01)

Patent

CA 1084507

ABSTRACT OF THE DISCLOSURE The present invention provides for preparing a compound of the formula ArO-CH2-CH2-CH-CH2-CH2-X (II) wherein Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 3-(or 5-)chloro-2-pyridyl, inden-4-(or 5-)ly, phenyl, monosubstituted phenyl or disubstituted phenyl and X represents a halogen chosen from chlorine, bromine or iodine which comprises reacting together compounds of the formula ArOH and XCH2-CHOH-CH2-CH2-X wherein Ar and X are as defined above. Such compounds are novel intermediates useful in the preparation of pharmaceuticals of the formula ArO-CH2-CHOH-CH2-CH2-NR1R2 Formula I wherein; Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-) chloro-2 pyridyl, phenyl, monosubstituted phenyl or disubstituted phenyl, R1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower cycloalkyl, R2 is hydrogen or lower alkyl, R1 and R2 together with the ad- jacent nitrogen form a heterocyclic residue.

312946

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