1-arylpyrimidine derivatives and pharmaceutical use thereof

Details 1-arylpyrimidine derivatives and pharmaceutical use thereof 1-arylpyrimidine derivatives and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

D

C07D 239/54 (2006.01) A61K 31/505 (2006.01) C07D 239/545 (2006.01) C07D 405/12 (2006.01) C07D 473/04 (2006.01) C07D 473/06 (2006.01)

Patent

CA 2154293

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): Image (I) wherein R1 is H, alkyl or aralkyl; Ar is 1-naphthyl, or a substituted or unsubstituted phenyl group; R4 is a substituted phenyl, a substituted styryl, 1- methylcyclohexyl, 4-methylcyclohexyl, 4-oxo-4H-pyran-2-yl or 2-oxo-2H-pyran-5-yl group; R5 and R6 are each independently H or alkyl; R3 is H, and R7 and R8 are combined together to be oxo, or else R3 and R7 are combined together to be another direct bond, and R5 and R8 are combined together to be a direct bond, or pharmaceutically acceptable salts thereof; and uses of such compounds as agents for treating allergic diseases.

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