1-arylsulphonyl, aryl(thio)carbonyl pyridazino derivatives...

C - Chemistry – Metallurgy – 07 – D

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C07D 237/26 (2006.01) A61K 31/50 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2236896

1-Arylsulphonyl, arylcarbonyl and aryl(thio)carbonyl pyridazino derivatives of general formula (I) and processes for making said derivatives are described. The novel derivatives are non- steroidal heterocyclic compounds which act as selective progestins and/or antiprogestins having a high in vitro affinity for either the uterine, breast or bone progestin receptor. As such, the non- steroidal heterocyclic derivatives are useful in contraception, menopause, osteoporosis or endometriosis. Image

L'invention porte sur des dérivés de pyridazine d'arylsulphonyl-1, d'arylcarbonyle et d'arylthiocarbonyle et sur leurs procédés de préparation. Ces dérivés de type nouveau sont des composés hétérocycliques non stéroïdiens agissant en tant que progestérones sélectives et/ou antiprogestérones ayant une affinité in vitro élevée par le récepteur des progestérones soit de l'utérus, soit du sein, soit des os. En tant que tels, ces dérivés hétérocycliques non stéroïdiens sont utiles dans le cadre de la contraception, de la ménopause, de l'ostéoporose ou de l'endométriose.

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