1-azatricyclic-4-benzylpiperazines

Details 1-azatricyclic-4-benzylpiperazines 1-azatricyclic-4-benzylpiperazines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) C07D 471/02 (2006.01) C07D 471/06 (2006.01) C07D 487/06 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2375851

Disclosed are 1-Azatricyclic-4-benzylpiperazine compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.

L'invention se rapporte à des composés 1-azatricyclico-4-benzylpipérazines qui sont utiles pour le traitement et/ou la prévention de troubles neurophysiologiques tels que, entre autres, la schizophrénie, les manies, la démence, la dépression, l'anxiété, les comportements compulsifs, la consommation abusive d'alcools et autres drogues, les troubles moteurs du type maladie de Parkinson et troubles du mouvement liés à la consommation d'agents neuroleptiques. L'invention concerne également des compositions pharmaceutiques, et notamment des compositions pharmaceutiques conditionnées. Les composés de cette invention s'avèrent utiles en tant que sondes destinées à la localisation de récepteurs de GABA¿A? dans des échantillons tissulaires.

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