C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/337.6, 260/3
C07D 203/16 (2006.01) C07D 403/12 (2006.01)
Patent
CA 1105474
ABSTRACT OF THE DISCLOSURE A class of 1-aziridine-carboxylic acid ester derivatives is provided having an immune-stimulating thera- peutic effect; the derivatives can be prepared by reacting an appropriate aziridine derivative with a haloformic acid ester; elimination of a halogen molecule from an appropriate dihalo derivative with concomitant cyclization to form the aziridine nucleus; elimination of nitrogen from a triazoline a nitrene with an appropriately substituted ethylene compound certain of the derivatives have additional utility as inter- mediates in the preparation of 2-cyano-1-aziridine-carboxamide a known immune-stimulating therapeutic compound.
292633
Bicker Uwe
Bosies Elmar
Gall Rudi
Heerdt Ruth
Ziegler Anna E.
Boehringer Mannheim G.m.b.h.
Sherman
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