1-azoniabicyclo¬2.2.1|heptane derivatives and pharmaceutical...

Details 1-azoniabicyclo¬2.2.1|heptane derivatives and pharmaceutical... 1-azoniabicyclo¬2.2.1|heptane derivatives and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2261808

A compound of formula (I), wherein A is a divalent radical selected from A1)-O- CO-; A2)-CH2-O-CO; A3)-O-CH2-CO-; A4)-O-CH2-CH2-; A5)-N(R1)-CO-; A6)-N(R1)-CO- CO; A7)-N(R1)-CH2-CH2-; A8)-O-CH2-; wherein R1 is hydrogen or (C1-C4)alkyl, and Am is (1). Said compound is useful as a neurokinin receptor antagonist.

L'invention a pour objet un composé de formule (I) dans laquelle: A représente un radical bivalent choisi parmi: A¿1?)-O-CO-; A¿2?)-CH¿2?-O-CO-; A¿3?)-O-CH¿2?-CO-; A¿4?)-O-CH¿2?-CH¿2?-; A¿5?)-N(R¿1?)-CO-; A¿6?)-N(R¿1?)-CO-CO-; A¿7?)-N(R¿1?)-CH¿2?-CH¿2?-; A¿8?)-O-CH¿2?-; dans lesquels R¿1? représente un hydrogène ou un (C¿1?-C¿4?)alkyle; Am représente (1). Application: antagonistes des récepteurs des neurokinines.

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