1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/14 (2006.01) A61K 31/495 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2222041

This invention relates to compounds of generic formula (I), to a process for preparation thereof, to a pharmaceutical composition comprising the same, and to a use of the same as a medicament. In formula (I), R1 is trihalo(lower)alkyl, R2 is trihalo(lower)alkyl, R3 is indolyl(lower)alkyl, -A- is -CH2- or (a), and -R4 is (b), (c) or (d) in which R5 is hydrogen or lower alkoxycarbonyl, R6 is hydrogen or lower alkanoyl, R7 is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkoxy(lower)alkanoyl, cyclo(lower)alkylcarbonyl, aroyl or lower alkylsulfonyl, or its pharmaceutically acceptable salt.

La présente invention concerne des composés de formule générale (I), un procédé de préparation de ces derniers, une composition pharmaceutique comprenant ces derniers et l'utilisation de ces derniers comme médicament. Dans la formule (I), R1 est un trihalo-alkyle inférieur, R2 est un trihalo-alkyle inférieur, R3 est un indolyl-alkyle inférieur, -A- est -CH2- ou (a), et -R4 est (b), (c) ou (d) où R5 est un hydrogène ou un alcoxy inférieur-carbonyle, R6 est un hydrogène ou un alcanoyle inférieur, R7 est un hydrogène, un alkyle inférieur, un alcanoyle inférieur, un alcoxy inférieur-carbonyle, un alcoxy inférieur-alcanoyle inférieur, un cycloalkyl inférieur-carbonyle, un aroyle ou un alkyle inférieur-sulfonyle, ou un sel pharmaceutiquement acceptable de ces derniers.

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