1-benzyl-1,2,3,6-tetrahydropyridine derivatives

Details 1-benzyl-1,2,3,6-tetrahydropyridine derivatives 1-benzyl-1,2,3,6-tetrahydropyridine derivatives

C - Chemistry, Metallurgy

07

D

260/294, 260/291

C07D 211/70 (2006.01)

Patent

CA 1118778

ABSTRACT The invention concerns novel 1-benzyl-1,2,3,6- tetrahydropyridine derivatives of the general formula: - Image I wherein R1 is hydrogen or a (1-4C)-alkyl radical, and benzene ring A bears one or two substituents selected from combinations of halogeno, (1-4C)- alkyl, (1-4C)-alkoxy, hydroxy, nitro, cyano, carboxamido, carboxyl, [(1-4C)-alkoxy]carbonyl, hydroxymethylene, amino, (1-4C)-alkanoylamino, (1-4C)-alkylsulphonamido, [(1-4C)-alkoxylcarbon- yloxy, (1-4C)-alkanoyloxy and optionally substituted benzoyloxy radicals, and their pharmaceutically acceptable salts; pharmaceutical compositions thereof; and analogy processes for their manu- facture. The tetrahydropyridine derivatives of formula I are preferably employed as their acid- addition salts and are inhibitors of the aggreg- ation of blood platelets and as such may be of application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. Representative compounds of formula I possessing particularly good blood platelet aggregation inhibitory properties are 1-(3,4-dichloro-, 4-chloro-3-hydroxy-, and 4-hydroxy-benzyl)- 1,2,3,6-tetrahydropyridine, preferably as their hydrochloride salts.

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