C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/300
C07D 207/263 (2006.01) C07D 207/26 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1242193
Abstract Pyrrolidinone derivatives, processes for their preparation and pharmaceutical compositions containing them A compound of formula I Image (I) wherein R1 represents a hydrogen atom or an alkyl group, R2 represents a phenyl group optionally mono- or disubstituted by a fluorine, chlorine, or bromine atom or a trifluoromethyl, alkyl, alkoxy, hydroxy or nitro group; or a pyridyl group linked to the methylene bridge in the 2, 3 or 4 position, and R3 and R4, which may be the same or different, represent a hydrogen atom or an alkyl group or the groups R3 and R4 together with the nitrogen atom to which they are attached form a saturated 5 or 6 membered ring which may contain an O or N atom as a further heteroatom and may optionally be substituted by methyl group; or they together form an imidazole ring and the aminoalkyl group is in the 4 or 5 position, and the acid addition salts thereof. Processes for the preparation of the new compound are also described. The new compounds have shown themselves effective, in animal experiments, in alleviatinq and/or curinq conditions of restricted cerebral performance and of hypoxia.
464585
Hinzen Dieter
Kuhn Franz J.
Lehr Erich
Schneider Claus
Walther Gerhard
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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