1-biphenylimidazole derivatives, their preparation and their...

Details 1-biphenylimidazole derivatives, their preparation and their... 1-biphenylimidazole derivatives, their preparation and their...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/695 (2006.01) C07D 233/90 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2229000

Compounds of formula (I): Image wherein, preferably, R1 represents an ethyl, propyl or butyl group; R2 represents a hydrogen atom or a methyl group; R3 represents a hydrogen atom; R4 represents a hydrogen atom or a methyl group; R5 represents a group of formula -COOR5a, in which R5a represents a hydrogen atom, a pivaloyloxymethyl group, an ethoxycarbonyloxymethyl group, a 1-(ethoxy-carbonyloxy)ethyl group, an isopropoxy- carbonyloxymethyl group, a 1-(isopropoxycarbonyloxy)ethyl group, a (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl group, or a phthalidyl group; R6 represents a hydrogen atom; R7 represents a carboxy group or a tetrazol-5-yl group at the 2-position of the benzene ring; and the benzene ring which bears the substituents represented by R6 and R7 is at the 4-position of the benzyl group to which it is attached; or a pharmaceutically-acceptable salt or ester thereof have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. They may be prepared, inter alia, by reacting a biphenylmethyl compound with an imidazole compound.

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