1-carboxy-azaalkanoylindoline-2-carboxylic acids

Details 1-carboxy-azaalkanoylindoline-2-carboxylic acids 1-carboxy-azaalkanoylindoline-2-carboxylic acids

C - Chemistry, Metallurgy

07

D

260/320

C07D 209/42 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1172258

Abstract of the disclosure The invention concerns hypotensive, antihypertensive and bradycardic compounds of the formula I Image (I) wherein Ph is unsubstituted 1,2-phenylene, or 1,2-phenylene substi- tuted by one to three identical or different members selected from lower alkyl, lower alkoxy, lower alkylenedioxy, hydroxy, halogeno and trifluoromethyl; R1 is hydrogen, lower alkyl or amino-lower alkyl; R2 is lower alkyl or HPh-lower alkyl; and each of R3, R4 and R5 is hydrogen or lower alkyl; the amides, mono- or di-lower alkylamides, lower alkyl esters, (amino, mono- or di-lower alkylamino, carboxy or carbo-lower alkoxy)-lower alkyl esters, or salts. They can be pre- pared, for example by hydrolysing a compound of the general formula Image wherein at least one of V and W is cyano, and the other is said free, amidized or esterified carboxy group.

389117

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