C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/207.7
C07D 209/42 (2006.01) C07D 213/30 (2006.01) C07D 307/89 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1199911
1-Carboxyalkanoylindoline-2-carboxylic acid esters Abstract of the disclosure The invention concerns hypotensive compounds of the general formula I Image (I) wherein Ph is unsubstituted 1,2-phenylene, or 1,2-phenylene substituted by one to three identical or different members selected from lower alkyl, lower alkoxy, lower alkylenedioxy, hydroxy, halogeno and tri- fluoromethyl; R? is hydrogen or HPh; each of R1, R2 and R3 is hydrogen or lower alkyl, n is an integer from 1 to 10, each of the symbols R4 represents a member selected from the group consisting of aryl-(lower) alkyl, in which aryl represents phenyl optionally substituted by lower alkyl, lower alkoxy or halogeno, or pyridyl, lower alkanoyloxy-(lower) alkyl, phthalidyl optionally substituted by lower alkyl, lower alkoxy or halogeno, (hydroxy, lower alkanoyloxy or lower alkoxy)-substituted (lower) alkoxymethyl, bicycloalkyloxy- carbonyl-(lower) alkyl, having up to 10 carbon atoms in the bicyclo- alkyl group, and being optionally substituted by lower alkyl, or 1-(lower alkoxycarbonyloxy)-lower alkyl; or one of the symbols R4 is hydrogen and the other is a radical R4 named above, or salts, thereof. They are prepared, for example, by esterifying free mono- or diacids corresponding to formula I.
426482
Fetherstonhaugh & Co.
Novartis Ag
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