1-cyanocyclopropyl-derivatives as cathepsin k inhibitors

Details 1-cyanocyclopropyl-derivatives as cathepsin k inhibitors 1-cyanocyclopropyl-derivatives as cathepsin k inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4353 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) C07D 471/10 (2006.01) C07D 471/14 (2006.01) C07D 491/04 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2689945

The present invention relates to compounds of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K.

L'invention concerne des composés de la formule (I) et des compositions destinés au traitement de maladies associées à l'activité cystéine protéase. Les composés de l'invention sont des inhibiteurs réversibles des cystéine protéases, entre autres des cathepsines B, K, C, F, H, L, O, S, W et X. L'invention offre un intérêt particulier dans le traitement de maladies associées à la cathepsine K.

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