1-diphenylmethyl-pyrazole derivatives as opioid receptor...

Details 1-diphenylmethyl-pyrazole derivatives as opioid receptor... 1-diphenylmethyl-pyrazole derivatives as opioid receptor...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4155 (2006.01) C07D 231/12 (2006.01) C07D 231/16 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2394209

This invention relates to 1-diphenylmethyl-pyrazole derivatives of formula (I): Image and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, R4 and R5 are defined herein, as ligands for opioid receptors, particularly the delta opioid receptor. The compounds of the invention have a broad range of therapeutic uses in the area of addictions, analgesia, immunotherapy, shock and brain injuries, neurological dysfunction, gastrointestinal dysfunction, among others.

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