1-furyl-3,4-dihydroisoquinolines, pharmaceutical...

Details 1-furyl-3,4-dihydroisoquinolines, pharmaceutical... 1-furyl-3,4-dihydroisoquinolines, pharmaceutical...

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 405/04 (2006.01) C07D 307/68 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1190545

ABSTRACT OF THE DISCLOSURE The invention relates to new l-furyl-3,4-dihydro- isoquinolines of general formula Image I wherein R1 and R2, which may be the same or different, represent a hydroxy or alkoxy group, R3 represents a cyano group or a Image , wherein Y represents a hydroxy group, an alkoxy group or a primary or secondary, substituted or unsubstituted, aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic amino group, and the acid addition salts thereof. The new compounds can be obtained by cyclising an amide of furan-3,4-dicarboxylic acid of general formula Image II wherein R1 to R3 are as hereinbefore defined, and they may be used as active substances for pharmaceutical compositions for the treatment of circulatory disorders and coronary diseases.

414620

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