1-galactose derivatives

Details 1-galactose derivatives 1-galactose derivatives

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) A61K 31/70 (2006.01) C07H 15/20 (2006.01)

Patent

CA 2330484

Disclosed are novel 1-galactose derivatives of formula (I) having a carbon- or nitrogen-containing aglycon linkage. The disclosed compounds inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. The disclosed compounds also inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors.

Cette invention a trait à de nouveaux dérivés de 1-galactose à liaison aglycone porteuse d'un carbone ou d'un azote. Les composés selon cette invention inhibent la fixation de toxines, telles que l'entérotoxine thermolabile ou la toxine cholérique, à leurs récepteurs, que ce soit in vitro ou in vivo. Ces mêmes composés inhibent également la fixation d'organismes entérovirulents (par exemple, des bactéries, des virus, des champignons et analogue) tels que Vibrio cholerae et des souches entérotoxigènes d'Escherichia coli, à leurs récepteurs de surface cellulaire.

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