C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/551 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2627089
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of - disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the .alpha.7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
La présente invention concerne généralement le domaine des ligands propres aux récepteurs nicotiniques de l~acétylcholine (nAChR), l'activation des nAChRs, et le traitement des états pathologiques associés aux récepteurs nicotiniques de l~acétylcholine défaillants ou présentant un dysfonctionnement, en particulier ceux affectant le cerveau. La présente invention concerne, en outre, de nouveaux composés (indazoles et benzothiazoles) qui agissent en tant que ligands sur le sous-type .alpha.7 nAChR, des procédés de préparation de tels composés, des compositions les contenant et leurs procédés d'utilisation.
Danca Mihaela Diana
Herbert Brian
Ma Jianguo
Nguyen Truc Minh
Schumacher Richard A.
Marks & Clerk
Memory Pharmaceuticals Corporation
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